TABLE 1

Preclinical evaluation of carisbamate

TestMouseRat
Maximal electroshock+a+b
Pentylenetetrazole+ab
Bicuculline+a+b
Picrotoxin+a+b
Corneal kindlingN.D.+b
Hippocampal kindlingN.D.+b
Lamotrigine-resistant amygdale kindled ratN.A.+b
6-Hz seizuresN.D.+b
Li+-pilocarpine SEN.D.+b
Audiogenic seizure+b+c
Genetic generalized spike-wave seizure (GAERS rat)N.A.+c
Chronic spontaneous seizure (Li+-pilocarpine SE)N.D.+d
Chronic spontaneous seizure (kainate SE)N.D.+e