TABLE 6

Effects of MK-801 alone and MK-801 combined with JWS-USC-75-IX on latencies, omissions, and trials completed in the standard version of the 5C-SRTT (0.5-s stimulus duration; n = 12)

Data are presented as mean ± S.E.M. The MK-801 dose was 0.05 mg/kg.

TreatmentLatencyOmissionsTrials Completed
CorrectIncorrectMagazine
s%
Vehicle + vehicle0.71 ± 0.041.72 ± 0.071.56 ± 0.105.06 ± 2.1999.70 ± 0.16
Vehicle + MK-8010.68 ± 0.031.56 ± 0.161.10 ± 0.16*7.90 ± 0.8671.50 ± 6.64*
JWS-USC-75-IX (0.1 mg/kg) + MK-8010.66 ± 0.021.84 ± 0.161.07 ± 0.05*6.70 ± 1.6387.08 ± 4.55
JWS-USC-75-IX (0.3 mg/kg) + MK-8010.70 ± 0.041.72 ± 0.211.22 ± 0.13*6.21 ± 1.4492.83 ± 5.09
JWS-USC-75-IX (1.0 mg/kg) + MK-8010.69 ± 0.031.48 ± 0.171.05 ± 0.05*6.04 ± 1.4185.88 ± 4.57
  • * p < 0.05, statistically significant difference from vehicle-treated group.

  • p < 0.05, statistically significant difference from the vehicle-MK-801-treated group.