Additional in vitro pharmacology of JWS-USC-75IX (functional assays)
| Drug | Muscarinic, M2 (h) | IC50 | ||||
|---|---|---|---|---|---|---|
| IC50 | KI | Slope | KB | AChE | BChE | |
| nM | nM | μM | ||||
| IC50/KI determination | 166.0 | 56.3 | −1.2 | |||
| JWS-USC-75-IX | 1.2 | 0.41 | −1.0 | |||
| (−)-Scopolamine MeBr | ||||||
| Functional agonist/antagonist determination | ||||||
| JWS-USC-75-IX | 3300.0 | 320.0 | ||||
| Methoctramine | 210.0 | 20.0 | ||||
| Cholinesterase inhibitor properties | ||||||
| JWS-USC-75-IX | 1.67 | 4.78 | ||||
| Galantamine | 1.12 | 8.29 | ||||
| Rivastigmine | 12.75 | 1.01 | ||||
| Donepezil | 0.05 | 6.43 | ||||
h, human.