Target | Inhibition (10.0 μM) |
---|---|
% | |
Adenosine transporter | −11.25 |
A1 (h) | 4.25 |
A2A (h) | 0.09 |
α1A | 55.89 |
α1B | 59.63 |
α2A (h) | 16.65 |
α2B | 53.20 |
α2C (h) | 22.12 |
β1 (h) | 15.80 |
β2 (h) | 13.88 |
DA transporter | 26.35 |
D1 (h) | 28.40 |
D2S (h) | 13.16 |
D3 (h) | 59.10 |
D4.4 (h) | −3.00 |
GABAA, agonist site | −15.06 |
GABAA, BDZ, α1 site | 38.74 |
GABAB | 20.94 |
Glutamate, AMPA site | −0.90 |
Glutamate, kainate site | 5.50 |
Glutamate, MK-801 site | −7.92 |
Glutamate, NMDA agonist site | −11.47 |
Glutamate, NMDA, PCP site | 11.83 |
Glutamate, NMDA, glycine (strychnine-insensitive site) | 8.06 |
Glycine, strychnine-sensitive | 6.47 |
Histamine, H1 | 10.48 |
Histamine, H2 | 92.72 |
Histamine, H3 | 63.43 |
Muscarinic, M1 (h, r) | 80.24 |
Muscarinic, M2 (h) | 96.69 |
Muscarinic, M3 (h) | 32.00 |
Muscarinic, M4 (h) | 73.80 |
Muscarinic, M5 (h) | 44.33 |
Nicotinic, neuronal (a-BnTx-insensitive) | 52.02 |
NE transporter (h) | 7.73 |
Opioid, δ2 (h) | −0.80 |
Opioid, μ (h) | 14.66 |
5-HT transporter | 67.83 |
5-HT1A (h) | 21.51 |
5-HT1D | 37.59 |
5-HT2A (h) | 16.67 |
5-HT2C (h) | 14.12 |
5-HT3 (h) | 17.59 |
5-HT4 | 77.81 |
5-HT5A (h) | 1.41 |
5-HT6 (h) | 25.36 |
5-HT7 (h) | 35.19 |
σ1 | 90.01 |
σ2 | 19.92 |
Ca2+ channel (L-type, dihydropyridine site) | 2.30 |
Ca2+ channel (N-type) | −10.36 |
GABA, chloride, TBOB site | 12.98 |
K+ channel, ATP-sensitive | 9.41 |
K+ channel, Ca2+-activated VI | 19.82 |
K+ channel, I[Kr] (HERG) (h) | 20.02 |
Na+ channel (site 2) | 6.50 |
NO, NOS (neuronal binding) | 8.17 |
Leukotriene, LTB4 (BLT) | 13.83 |
Leukotriene, LTD4 (CysLT1) | −8.58 |
Thromboxane A2 (h) | −7.54 |
Angiotensin II, AT1 (h) | 0.25 |
Bradykinin, BK2 | 24.55 |
Endothelin, ETA (h) | −11.04 |
Neurokinin, NK1 | 21.31 |
Neuropeptide, NPY2 (h) | 0.10 |
Acetylcholinesterase (h) | 87.98 |
5-HT, 5-hydroxytryptamine; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDZ, benzodiazepine; DA, dopamine; h, human; HERG, human ether-a-go-go-related gene; NE, norepinephrine; NO, nitric oxide; NOS, nitric-oxide synthase; PCP, phencyclidine; r, rat; TBOB, [3H]t-butylbicycloorthobenzoate.