TABLE 1

IC₅₀ values of AS1928370 for TRPs in Ca²⁺ flux assay

Values are mean ± S.E.M.

Activator	TRPV1		TRPV4 Hypotonic	TRPA1 AITC	TRPM8 Menthol
Activator	Capsaicin	Proton	TRPV4 Hypotonic	TRPA1 AITC	TRPM8 Menthol
	μM
Human	0.30 ± 0.02	1.5 ± 0.50	>10^{^a}	>10^{^a}	>10^{^a}
Rat	0.88 ± 0.02	>10^{^a}	>10^{^a}	>10^{^a}	>10^{^a}

AITC, allyl isothiocyanate.
↵a Less than 20% of the responses were inhibited, and no agonistic responses were observed at 10 μM.