Individual and mean plasma and brain concentrations and some basic pharmacokinetic parameters after single subcutaneous administration at 40 mg/kg of JNJ-1930942 in male Swiss mouse
Three male Swiss mice (numbered 1–3) received a single dose of 40 mg/kg s.c. JNJ-1930942. Plasma and brain samples were collected at different time intervals after compound administration. Concentrations of JNJ-1930942 were determined as described under Materials and Methods and plotted as a function of time.
| JNJ-1930942 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Plasma | Brain | |||||||
| 1 | 2 | 3 | Mean ± SD | 1 | 2 | 3 | Mean ± SD | |
| ng/ml | ng/g | |||||||
| Time | ||||||||
| 0.5 h | 5260 | 7730 | 4770 | 5920 ± 1587 | 2330 | 2000 | 1410 | 1913 ± 466 |
| 1 h | 2780 | 3770 | 2570 | 3040 ± 641 | 893 | 2070 | 994 | 1319 ± 652 |
| 2 h | 1170 | 1780 | 2120 | 1690 ± 481 | 363 | 448 | 560 | 457 ± 99 |
| 4 h | 167 | 247 | 115 | 176 ± 66 | 60.6 | 72.3 | 45.4 | 59.4 ± 13.5 |
| 8 h | 14.6 | 92.5 | 28.9 | 45.3 ± 41.5 | 10.5 | 24.1 | 11.4 | 15.3 ± 7.6 |
| Cmax (ng/ml) | 5920 | 1913 | ||||||
| Tmax (h) | 0.5 | 0.5 | ||||||
| t1/2 (4–8 h) (h) | 2.0 | 2.0 | ||||||
| AUC0–8 h (ng · h · ml−1) | 7664 | 2610 | ||||||
| AUC∞ (ng · h · ml−1) | 7797 | 2655 | ||||||
| Brain-to-plasma ratio | 0.3 | |||||||