TABLE 3

Hepatic pharmacokinetics of Gd-DTPA and Gd-BOPTA by compartmental analysis

Values are presented as means ± S.D.

	Perfused [BOPTA]						p
	40 μM	100 μM	200 μM	400 μM	800 μM	1600 μM	p
k₁₂
SD	1.4 ± 0.2	1.7 ± 0.2	1.4 ± 0.3	1.4 ± 0.2	1.3 ± 0.4	1.3 ± 0.2	0.42
TR⁻	1.4 ± 0.2	1.9 ± 0.4	1.2 ± 0.3	1.7 ± 0.4	1.6 ± 0.2	1.3 ± 0.3	0.36
k₂₄ BOPTA
SD	1.6 ± 0.2	1.7 ± 0.2	1.5 ± 0.2	1.0 ± 0.4	1.0 ± 0.4	0.5 ± 0.11	0.02
TR⁻	0.8 ± 0.1	0.7 ± 0.1	0.6 ± 0.1	0.5 ± 0.1	0.3 ± 0.1	0.2 ± 0.1	0.01
k₂₄ DTPA
SD	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0.76
TR⁻	0	0	0	0	0	0
k₄₂
SD	0.06 ± 0.01	0.08 ± 0.01	0.12 ± 0.04	0.10 ± 0.06	0.44 ± 0.17	0.12 ± 0.09	0.05
TR⁻	<0.005	<0.005	<0.005	<0.005	<0.005	<0.005	0.23
k₄₆
SD	0.09 ± 0.01	0.09 ± 0.01	0.11 ± 0.03	0.12 ± 0.01	0.15 ± 0.01	0.12 ± 0.03	0.06
TR⁻	0	0	0	0	0	0
k₄₅
SD	0.02 ± 0.01	0.04 ± 0.01	0.08 ± 0.03	0.10 ± 0.02	0.26 ± 0.05	0.18 ± 0.06	0.006
TR⁻	0	0	0	0	0	0
k₅₆
SD	0.03 ± 0.01	0.04 ± 0.01	0.05 ± 0.01	0.05 ± 0.01	0.05 ± 0.01	0.04 ± 0.01	0.10
TR⁻	0	0	0	0	0	0
k₂₃
SD	9.6 ± 1.5	10.7 ± 2.4	10.9 ± 1.3	10.3 ± 0.6	9.1 ± 2.3	10.1 ± 1.5	0.65
TR⁻	12.1 ± 1.8	11.7 ± 2.5	10.3 ± 2.7	11.9 ± 1.5	10.2 ± 1.5	9.7 ± 1.6	0.54

SD, Sprague-Dawley rats.