| nM | % | nM | % |
1321N1 Cells | | | | |
(R)-isoproterenol | 0.05 ± 0.01 | 88.7 ± 1.89 | 17.0 ± 5.62 | 100 |
(R,R′)-fenoterol | 0.15 ± 0.07 | 84.3 ± 6.95 | 15.9 ± 2.04 | 162.1 ± 16.9 |
(S,S′)-fenoterol | 184 ± 26.1 | 85.0 ± 12.0 | 1856 ± 925 | 31.1 ± 21.2 |
(R,R′)-4-methoxyfenoterol | 0.17 ± 0.02 | 85.7 ± 4.19 | 20.9 ± 6.21 | 71.8 ± 5.00 |
(R,R′)-4-methoxy-1-naphthylfenoterol | 3.98 ± 0.28 | 87.7 ± 1.70 | 68.9 ± 13.1 | 34.6 ± 6.48 |
(R,S′)-4-methoxy-1-naphthylfenoterol | 4.37 ± 0.70 | 84.0 ± 0.82 | 88.2 ± 19.6 | 53.3 ± 23.2 |
U118 Cells | | | | |
(R)-isoproterenol | 1.75 ± 0.39 | 68.3 ± 5.63 | 55.6 ± 12.0 | 100 |
(R,R′)-fenoterol | 5.40 ± 3.59 | 61.9 ± 6.34 | 57.3 ± 14.36 | 67.1 ± 7.53 |
(S,S′)-fenoterol | 815 ± 126 | 52.0 ± 2.94 | 4809 ± 1619 | 20.1 ± 8.73 |
(R,R′)-4-methoxyfenoterol | 7.05 ± 2.18 | 59.7 ± 6.80 | 64.6 ± 12.9 | 60.7 ± 2.28 |
(R,R′)-4-methoxy-1-naphthylfenoterol | 41.1 ± 6.01 | 51.0 ± 4.32 | 56.70 ± 15.67 | 22.8 ± 7.21 |
(R,S′)-4-methoxy-1-naphthylfenoterol | 25.8 ± 8.03 | 49.3 ± 8.35 | 46.77 ± 9.02 | 16.1 ± 1.88 |