TABLE 6

Pharmacokinetic parameters of imidafenacin in rat serum, bladder, and submaxillary gland after the oral administration of imidafenacin (1.57 and 6.26 μmol/kg)

Each value represents the mean ± S.E. for four rats.

Pharmacokinetic ParametersSerumBladderSubmaxillary Gland
Imidafenacin (1.57 μmol/kg)
    Cmax (pmol/ml, pmol/g)1.90 ± 0.7850.6 ± 4.5*30.3 ± 9.0
    t1/2 (h)2.68 ± 1.363.18 ± 1.082.53 ± 1.34
    AUC (pmol · h−1 · ml−1, pmol · h−1 · g−1)7.58 ± 1.29268 ± 6**153 ± 6
    AUCtissue/AUCserum35.4 ± 6.0**20.2 ± 3.5
    Cltot/F (l · h−1 · kg−1)207 ± 31
    Vdss/F (l/kg)1016 ± 299
Imidafenacin (6.26 μmol/kg)
    Cmax (pmol/ml, pmol/g)5.81 ± 0.53132 ± 6***56.9 ± 6.2
    t1/2 (h)2.11 ± 0.702.15 ± 0.861.83 ± 0.94
    AUC (pmol · h−1 · ml−1, pmol · h−1 · g−1)22.8 ± 1.8803 ± 9**323 ± 6
    AUCtissue/AUCserum35.2 ± 11.0*14.2 ± 7.3
    Cltot/F (l · h−1 · kg−1)274 ± 16
    Vdss/F (l/kg)1396 ± 211

  • ↵* P < 0.05, significant difference from the submaxillary gland group.

  • ↵** P < 0.01, significant difference from the submaxillary gland group.

  • ↵*** P < 0.001, significant difference from the submaxillary gland group.