TABLE 1

Cognitive domains modulated by histamine and H₃ antagonists in the different preclinical models that have been extensively used to detect the procognitive effect of novel agents

	Cognitive Domains
	Attention–Impulsivity^{^a}	Short-Term Memory^{^b}	Working Memory^{^c}	Long-Term Memory^{^d}	Spatial Memory^{^e}
Histamine		+		+	+
Thioperamide	+	+	+	+	+
BF2.649 (pitolisant)			+
ABT-239	+	+	+	+	+
ABT-288	+	+		+	+
GSK189254	+			+	+
JNJ-10181457	+		+
PF-03654746				+

+ indicates that efficacy in this model was demonstrated.
↵a Evaluated in the five-trial inhibitory avoidance test in SHR pups or the five-choice serial reaction time test.
↵b Short-term memory evaluated in the social recognition rat test.
↵c Working memory in the radial maze, Y-maze, object recognition, or delayed nonmatching to position test.
↵d Long-term memory or consolidation in the inhibitory avoidance test with retention measured 24 h after one-trial learning.
↵e Spatial memory evaluated in the water maze or Barnes maze.