TABLE 1

Genes encoded by transcripts that were significantly altered in mouse striatum after chronic pharmacological inhibition of PDE10A activity, after correction for multiple comparisons

A comparison between PDE10A KO and WT striatum for each pharmacologically regulated gene is shown with the associated FDR corrected p value and fold change. Significant changes across treatments are underlined. No significant pharmacologically induced differences were observed after TP-10 treatment in the PDE10A knockout animals, consistent with the specificity of these effects via PDE10A inhibition. Genes represented in bold were reported to be cAMP-responsive genes by Zhang et al. (2005).

Gene Symbol	Gene Name	Veh vs. TP-10		KO vs. WT		KO + TP-10 vs. Veh		Affymetrix ID
Gene Symbol	Gene Name	FDR P Value	Fold Change	FDR P Value	Fold Change	FDR P Value	Fold Change	Affymetrix ID
Csda	Cold shock domain protein A	0.01	7.86	0.89	1.76	0.83	−1.22	1453238_s_at
1200016E24Rik	Mus musculus RIKEN cDNA 1200016E24 gene	0.02	7.65	0.89	1.76	1.00	1.01	1452418_at
4631426E05Rik	Hypothetical protein MGC39715	0.04	3.58	0.89	1.48	0.99	−1.06	1453177_at
Mm0.405423	Mus musculus adult male corpus striatum cDNA, RIKEN clone:C030023B07	0.00	3.36	0.00	2.95	1.00	−1.02	1460043_at
Nnat	Neuronatin	0.00	2.69	0.00	2.36	0.99	1.03	1423506_a_at
Irak3	Interleukin-1 receptor-associated kinase M	0.01	2.34	0.69	1.38	0.98	−1.05	1435040_at
Myo3b	Myosin IIIB	0.01	2.20	0.26	1.64	0.98	1.05	1459299_at
Dlk1	Delta-like 1 homolog (Drosophila)	0.03	1.94	0.49	1.45	0.96	−1.08	1449939_s_at
Pde1c	PDE1C (Calmodulin 3′,5′cyclic nucleotide phosphodiesterase 1C/HSPDE1C)	0.02	1.94	0.10	1.69	0.88	1.18	1440374_at
Gpr149	G protein-coupled receptor 149	0.02	1.92	0.93	1.16	0.98	−1.05	1438210_at
*Arg2*	Arginase, type II	0.04	1.91	0.58	1.40	0.99	1.01	1418847_at
Smpdl3b	Sphingomyelin phosphodiesterase, acid-like 3B	0.03	1.86	0.43	1.45	1.00	−1.02	1417300_at
BC022623	Family with sequence similarity 43, member A	0.00	1.84	0.00	1.83	0.95	1.05	1426734_at
*Ppp1r2*	Protein phosphatase 1, regulatory (inhibitor) subunit 2	0.02	1.78	0.86	1.20	0.99	−1.02	1456830_at
*Pdyn*	Prodynorphin	0.03	1.76	0.00	2.61	0.87	−1.07	1416266_at
Rgs5	Regulator of G-protein signaling 5	0.04	1.71	0.65	1.30	0.93	−1.09	1420941_at
Pde1c	PDE1C (Calmodulin 3′,5′cyclic nucleotide phosphodiesterase 1C/HSPDE1C)	0.02	1.70	0.71	1.24	0.95	−1.04	1436251_at
Syt10	Synaptotagmin X	0.02	1.67	0.25	1.41	1.00	−1.01	1450347_at
Filip1	Filamin A interacting protein 1	0.03	1.63	0.82	1.19	0.97	−1.03	1436650_at
Rgs5	Regulator of G-protein signaling 5	0.03	1.62	0.62	1.26	0.91	−1.07	1417466_at
*Ppp1r2*	Protein phosphatase 1, regulatory (inhibitor) subunit 2	0.00	1.59	0.35	1.25	0.73	−1.39	1448684_at
Hs6st2	Heparan-sulfate 6-sulfotransferase 2	0.03	1.56	0.68	1.22	0.94	1.09	1450047_at
1700012A16Rik	RIKEN cDNA 1700012A16 gene	0.03	1.55	0.64	1.24	0.98	−1.03	1429324_at
Frem2	FRAS1 related extracellular matrix protein 2	0.03	1.54	0.24	1.37	0.96	−1.06	1457038_at
Dgat2	Diacylglycerol O-acyltransferase homolog 2 (mouse)	0.01	1.54	0.03	1.46	1.00	−1.03	1422678_at
D10Ertd438e	Chromosome 6 open reading frame 68	0.03	1.54	0.29	1.34	1.00	−1.02	1419915_at
Lor	Loricrin	0.02	1.53	0.11	1.42	0.92	1.11	1448745_s_at
Dgat2	Diacylglycerol O-acyltransferase homolog 2 (mouse)	0.04	1.53	0.06	1.51	0.75	−1.14	1422677_at
Slc7a8	Solute carrier family 7 (cationic amino acid transporter, y + system), member 8 (SLC7A8)	0.00	1.53	0.00	1.63	0.85	−1.29	1417929_at
Itm2a	Integral membrane protein 2A	0.02	1.51	0.53	1.23	0.22	1.42	1423608_at
Wdr17	WD repeat domain 17	0.00	1.48	0.11	1.28	0.92	1.14	1435392_at
Dcbld1	Homo sapiens cDNA FLJ30900 fis, clone FEBRA2005752.	0.03	1.46	0.27	1.29	0.92	−1.71	1418966_a_at
Rasl10b	RAS-like, family 10, member B	0.03	1.45	0.48	1.23	0.89	−1.10	1433566_at
*Avpi1*	Arginine vasopressin-induced 1	0.01	1.41	0.03	1.36	0.95	−1.11	1423122_at
Hist3 h2ba	Histone 3, H2bb	0.01	1.41	0.20	1.23	0.95	−1.14	1449482_at
Lor	Loricrin	0.02	1.40	0.08	1.34	0.77	−1.11	1420183_at
1110018G07Rik	KIAA0317	0.01	1.39	0.41	1.20	1.00	−1.04	1433767_at
0610012D17Rik	Hypothetical protein MGC33212	0.04	1.39	0.79	1.14	0.91	−1.73	1428972_at
Esm1	Endothelial cell-specific molecule 1	0.05	1.36	0.88	1.11	0.90	−1.06	1449280_at
*Chmp1b*	Chromatin modifying protein 1B	0.02	1.35	0.00	1.49	0.99	1.02	1418817_at
Ninj1	Ninjurin 1	0.03	1.33	0.44	1.18	0.99	−1.05	1441281_s_at
Tmem35	Transmembrane protein 35	0.05	1.31	0.37	1.20	1.00	−1.01	1416710_at
Tmem41a	Transmembrane protein 41A	0.03	1.31	0.00	1.42	0.96	−1.08	1424191_a_at
*Erlin1*	ER lipid raft associated 1	0.04	1.30	0.87	1.09	0.98	−1.05	1424210_at
1110059G10Rik	KIAA1143	0.04	1.30	0.87	1.09	1.00	−1.02	1418048_at
D10Ertd438e	Chromosome 6 open reading frame 68	0.02	1.30	0.38	1.16	0.95	−1.05	1419914_s_at
Pigx	Phosphatidylinositol glycan, class X	0.03	1.29	0.14	1.23	0.64	−1.05	1425134_a_at
Abat	4-Aminobutyrate aminotransferase	0.01	1.29	0.07	1.23	1.00	−1.01	1433855_at
*Znf346*	Zinc finger protein 346	0.04	1.28	0.88	1.08	0.91	1.13	1417088_at
Nudt11	Nudix (nucleoside diphosphate linked moiety X)-type motif 11	0.01	1.28	0.12	1.19	0.92	−1.07	1426887_at
*Ppp2r5b*	Protein phosphatase 2, regulatory subunit B (B56), β isoform	0.01	1.27	0.02	1.24	0.95	−1.07	1426811_at
Tmem68	Transmembrane protein 68	0.01	1.26	0.06	1.20	0.93	1.10	1423649_at
Gpr176	G protein-coupled receptor 176	0.02	1.25	0.29	1.15	0.94	−1.05	1442116_at
Fkbp1a	FKBP (12 FK-506)	0.03	1.25	0.84	1.08	0.87	−1.16	1448184_at
Ppp1r7	Protein phosphatase 1, regulatory subunit 7	0.04	1.24	0.05	1.25	0.98	−1.06	1417919_at
*Cbx4*	Chromobox homolog 4 (Pc class homolog, Drosophila)	0.01	1.23	0.01	1.24	0.89	1.11	1419583_at
Znrf1	Zinc and ring finger 1	0.04	1.22	0.03	1.26	0.95	−1.09	1424384_a_at
*Bzw2*	Basic leucine zipper and W2 domains 2	0.03	1.22	0.63	1.10	0.80	−1.16	1423456_at
Rnf103	Ring finger protein 103	0.02	1.22	0.45	1.11	0.90	−1.23	1448434_at
Gad1	Glutamate decarboxylase 1 (brain, 67 kDa) (GAD1)	0.05	1.21	0.87	1.07	0.96	−1.03	1416561_at
*Hif1a*	Hypoxia-inducible factor 1, α subunit (basic helix-loop-helix transcription factor)	0.03	1.19	0.55	1.10	0.98	1.07	1416035_at
Rwdd4a	RWD domain containing 4A	0.04	1.18	0.54	1.10	1.00	−1.02	1424243_at
Rps2	Ribosomal protein S2	0.04	1.17	0.33	1.11	0.91	−1.16	1431765_a_at
KIAA1109	KIAA1109	0.01	1.17	0.65	1.06	0.93	−1.12	1427016_at
Tsc22d1	TSC22 domain family 1	0.03	1.16	0.25	1.11	0.95	−1.05	1425742_a_at
*Cox7a2l*	Cytochrome c oxidase subunit VIIa polypeptide 2-like	0.04	1.15	0.98	−1.02	0.97	−1.03	1421772_a_at
*Phb2*	Prohibitin 2	0.05	1.15	0.99	1.02	0.95	−1.15	1416202_at
Ngfrap1	Nerve growth factor receptor (TNFRSF16) associated protein 1	0.04	1.13	0.18	1.10	0.98	−1.08	1428842_a_at
*Usmg5*	Up-regulated during skeletal muscle growth 5	0.02	1.11	0.58	1.05	0.98	−1.07	1448179_at
*Slc25a3*	Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.03	1.10	0.43	1.06	0.74	1.15	1416300_a_at
*Pttg1*	Pituitary tumor-transforming 1	0.02	−1.21	0.11	−1.16	0.91	−1.03	1438390_s_at
Snrpb	Small nuclear ribonucleoprotein polypeptide N	0.01	−1.23	0.46	−1.11	0.97	−1.04	1437193_s_at
D630004N19Rik	RIKEN cDNA D630004N19 gene	0.03	−1.26	0.94	−1.06	1.00	1.03	1442016_at
Mm0.326577	Mus musculus similar to cadherin 11	0.04	−1.26	0.65	−1.12	0.99	−1.02	1441565_at
Rnf144a	Ring finger protein 144A	0.01	−1.29	0.00	−1.37	0.99	1.04	1438404_at
Chat	Choline O-acetyltransferase	0.02	−1.38	0.03	−1.37	0.99	−1.04	1443372_at
Ankrd35	Ankyrin repeat domain 35	0.03	−1.38	0.23	−1.27	0.87	−1.10	1438474_at
Hdac4	Histone deacetylase 4	0.03	−1.38	0.85	−1.11	0.53	−1.14	1436758_at
Camkk2	Ca²⁺/calmodulin-dependent protein kinase kinase β (CAMKKB)	0.03	−1.45	0.55	−1.21	1.00	−1.01	1455401_at
Il17rc	Interleukin 17 receptor C	0.01	−1.45	0.05	−1.36	0.85	−1.60	1419671_a_at
Eif2c4	Eukaryotic translation initiation factor 2C, 4	0.00	−1.46	0.01	−1.39	0.92	−1.20	1453289_at
Nfix	Nuclear factor I/X (CCAAT-binding transcription factor)	0.01	−1.47	0.76	−1.15	0.84	1.16	1436363_a_at
Fst	Follistatin	0.04	−1.48	0.08	−1.44	0.95	−1.08	1421365_at
Eif2c4	Eukaryotic translation initiation factor 2C, 4	0.00	−1.48	0.03	−1.39	0.94	−1.04	1429779_at
Cacnb3	Dihydropyridine-sensitive L-type calcium channel β3 subunit	0.01	−1.50	0.57	−1.20	0.98	−1.02	1448656_at
Camkk2	Ca²⁺/calmodulin-dependent protein kinase kinase β (CAMKKB)	0.02	−1.53	0.31	−1.32	0.88	−1.09	1424474_a_at
Ptprv	Protein tyrosine phosphatase, receptor type, V (pseudogene)	0.01	−1.58	0.00	−1.74	1.00	1.01	1449957_at
1110032E23Rik	Hypothetical protein DKFZp434L142	0.03	−1.60	0.01	−1.72	0.97	−1.04	1416805_at
Kcna6	Voltage-gated potassium channel protein KV1.6	0.03	−1.64	0.57	−1.29	0.93	−1.16	1441049_at
EG625121	Predicted gene, EG625121	0.03	−1.65	0.33	−1.38	0.99	−1.01	1457143_at
Fst	Follistatin	0.01	−1.65	0.03	−1.62	1.00	−1.01	1434458_at
Kalrn	Kalirin, RhoGEF kinase	0.01	−1.66	0.99	−1.06	1.00	1.00	1436066_at
1110032E23Rik	Hypothetical protein DKFZp434L142	0.00	−1.91	0.00	−2.24	0.96	−1.04	1429637_at
2210419I08Rik	RIKEN cDNA 2210419I08 gene	0.01	−1.93	0.25	−1.52	1.00	−1.02	1441368_at
*Clspn*	Claspin homolog (Xenopus laevis)	0.00	−2.78	0.00	−2.55	1.00	−1.01	1456280_at