Effects of APP, EHNA, or dexamethasone (DEX) on food intake, body weight, and spleen weight
Treatments with test drugs were started at day 5 from the induction of colitis with DNBS; systemic parameters of inflammation were assessed on day 11. Each value represents the mean ± S.E.M. obtained from eight animals.
| Inflammatory Parameters | DNBS (day 11) | +APP (15 μmol/kg/day) | +EHNA (90 μmol/kg/day) | +DEX (0.25 μmol/kg/day) |
|---|---|---|---|---|
| Food intake (g) | 20.0 ± 4.0 | 33.5 ± 4.5* | 28.0 ± 3.5* | 20.5 ± 5.0 |
| Body weight variation (%) | +4.9 ± 2.5 | +18.0 ± 3.0* | +16.8 ± 3.2* | +1.2 ± 1.7 |
| Spleen weight (%) | 137.4 ± 6.2 | 108.7 ± 3.5* | 115.0 ± 4.8* | 105.4 ± 3.7* |
↵* P < 0.05 significant difference vs. DNBS.