TABLE 1

IC50 values of TAK-438, SCH28080, and lansoprazole against porcine H+, K+-ATPase

pH 6.5pH 7.5
IC50CIIC50CI
μM
TAK-4380.019(0.017–0.023)0.028(0.023–0.033)
SCH280800.14(0.12–0.17)2.5(1.6–3.8)
Lansoprazole7.6(3.6–16)66(47–86)