TABLE 2

Effect of STZ treatment on isoproterenol-mediated inhibition of EFS contraction in urinary bladder from wild-type and M2 KO mice

The parameter -log α is a measure of the role of the M2 receptor in opposing isoproterenol-induced relaxation. The parameters were estimated from the data in Figs. 6 and 7. Mean estimates ± S.E.M. are shown, and the number of replicates is indicated within parentheses.

M2 Receptor Disinhibitory Effect
Denuded Bladder (−log α)Intact Bladder (−log α)
8 to 9 Weeks after treatment
    Vehicle0.74 ± 0.18 (3–6)1.24 ± 0.098 (3–6)
    STZ1.01 ± 0.071* (4–5)0.860 ± 0.051** (4–5)
20 to 24 Weeks after treatment
    Vehicle0.076 ± 0.046 (4–5)0.53 ± 0.098 (4–5)
    STZ0.88 ± 0.10*** (3–4)0.69 ± 0.050 (3–4)

  • ↵* P < 0.05, significantly different from vehicle.

  • ↵** P < 0.01, significantly different from vehicle.

  • ↵*** P < 0.0001, significantly different from vehicle.