Treatment effects on glycemic and inflammatory parameters
Fasted plasma glucose, insulin, CRP, and MCP-1 concentrations were measured at baseline, after 3, 5, and 7/8 weeks of treatment, and after 4 weeks of washout, as outlined under Materials and Methods. Data are expressed as mean values ± S.E.M. (n = 10 animals per group).
| Baseline | 3 Weeks Treatment | 5 Weeks Treatment | 7/8 Weeks Treatment | 4 Weeks Washout | |
|---|---|---|---|---|---|
| Glucose (mg/dl) | |||||
| Vehicle | 57.6 ± 2.3 | 52.0 ± 1.2 | 53.7 ± 1.3 | 56.1 ± 2.0 | 56.2 ± 1.3 |
| Pair-fed | 55.0 ± 1.8 | 51.3 ± 1.8 | 56.7 ± 2.0 | 55.3 ± 2.7 | 57.4 ± 2.6 |
| PF-95453 | 54.2 ± 2.1 | 61.4 ± 3.6* | 55.7 ± 2.9 | 56.4 ± 3.3 | 51.5 ± 2.9 |
| Insulin (μU/ml) | |||||
| Vehicle | 32.9 ± 7.2 | 28.6 ± 6.6 | 27.5 ± 8.2 | 35.9 ± 9.4 | 26.9 ± 9.4 |
| Pair-fed | 23.1 ± 3.5 | 19.8 ± 3.3 | 27.8 ± 6.1 | 33.6 ± 7.8 | 21.3 ± 4.4 |
| PF-95453 | 22.3 ± 4.0 | 55.5 ± 10.3* | 24.1 ± 5.5 | 27.5 ± 7.6 | 14.8 ± 4.0 |
| CRP (ng/ml) | |||||
| Vehicle | 361 ± 55 | 356 ± 52 | 296 ± 42 | 306 ± 50 | 318 ± 48 |
| Pair-fed | 339 ± 54 | 367 ± 62 | 264 ± 38 | 265 ± 42 | 286 ± 54 |
| PF-95453 | 331 ± 38 | 230 ± 33* | 259 ± 25 | 249 ± 32 | 330 ± 44 |
| MCP-1 (pg/ml) | |||||
| Vehicle | 154 ± 19 | 165 ± 22 | 168 ± 16 | 139 ± 18 | 162 ± 12 |
| Pair-fed | 152 ± 15 | 167 ± 15 | 175 ± 21 | 168 ± 18 | 182 ± 21 |
| PF-95453 | 127 ± 14 | 136 ± 15 | 114 ± 10* | 121 ± 11 | 226 ± 18 |
↵* P < 0.05 vs.vehicle-treated and pair-fed groups.