Compounds tested for their effects on human CYP3A4 and CYP2D6 enzyme activities
Data are represented as mean IC50 ± S.E.M. (μM).
| Compound | CYP3A4 | CYP2D6 |
|---|---|---|
| QC-15 | 0.6 ± 0.1 | 3.9 ± 0.2 |
| QC-53 | 8 ± 1 | 0.4 ± 0.2 |
| QC-57 | 5 ± 1 | 34 ± 8 |
| QC-65 | 23 ± 4 | 1.7 ± 0.2 |
| QC-86 | >100 | 23 ± 1 |
| QC-104 | 90 ± 10 | >100 |
| QC-118 | >100 | 4.9 ± 0.3 |
| QC-143 | 56 ± 8 | >100 |