Estimated values of pharmacokinetic parameters with their corresponding CV% obtained by noncompartmental analysis of mean rHuEPO serum concentrations after intravenous administration of 1350 IU/kg three times a week over 6 weeks
| Parameter (unit) | Definition | 1350 IU/kg Three Times a Week for 6 Weeks | ||
|---|---|---|---|---|
| PK1 (IV1) | PK2 (IV8) | PK3 (IV12) | ||
| AUC (IU/ml·h) | Area under the concentration curve | 49.4 (2.3) | 77.6 (12) | 104.2 (2.7) |
| CLTotal (ml/h/kg) | Total clearance | 27.3 (2.4) | 17.4 (16.5) | 12.9 (2.7) |
| MRT (h) | Mean residence time | 5.58 (4.4) | 7.19 (7.9) | 8.40 (10.3) |
| Vss (ml/kg) | Steady-state volume of distribution | 152 (2.3) | 125 (52.3) | 108 (6.3) |