Comparison of the potencies (ED50) of the subplantar administration of l-NIL, NANT, ODQ, or Rp-8-pCPT-cGMPs (Rp-8) to suppress the mechanical allodynia (von Frey test), thermal hyperalgesia (plantar test), and thermal allodynia (cold-plate test) induced by nerve injury in WT mice at 21 days after CCI induction
Data are expressed as ED50 values (nanomoles) with 95% confidence limits determined on the quantal data of five to six animals per dose.
| Test | l-NIL | NANT | ODQ | Rp-8 | Ratio (l-NIL/NANT) | Ratio (ODQ/Rp-8) |
|---|---|---|---|---|---|---|
| Mechanical allodynia | 465.6 (423.7–511.6) | 118.0 (115.1–120.9) | 22.5 (12.5–40.2) | 7.7 (6.3–9.3) | 3.9 | 2.9 |
| Thermal hyperalgesia | 462.2 (394.7–541.3) | 101.4 (97.4–105.5) | 21.7 (13.0–36.4) | 9.0 (8.1–10.1) | 4.5 | 2.4 |
| Thermal allodynia | 334.8 (283.4–395.6) | 90.6 (61.3–133.9) | 26.6 (19.8–35.6) | 7.3 (6.1–8.8) | 3.7 | 3.6 |