Agonist profile of ABT-107 at nAChRs assayed by FLIPR Ca2+ imaging
| Receptor, Assay Type | EC50 (nM); Maximal Effecta vs. 100 μM (−)-Nicotine | n |
|---|---|---|
| α4β2, Human, HEK-293 | >100,000; 4 ± 1% | 14 |
| α3β4*, Human, IMR-32 | >100,000; 6 ± 1% | 14 |
| α4β4, Human, HEK-293 | 2700 (2000–3400); 12 ± 1% | 9 |
| α7, Rat cortical cultures, with A-867744 | 10.9 (6.8–17.3) | 5 |
| α7, Human, IMR-32 | ||
| with A-867744 | 12.6 (10.8–14.7) | 4 |
| with PNU-120596 | 0.7 (0.5–0.9) | 5 |
| with PNU-120596 + MLA | 10.4 (8.1–13.2) | 5 |
↵a Values are expressed as means with 95% CIa or mean ± S.E.M.