Wild-Type Hα4β2 nAChRs | Mutant Hα4β2 nAChRs | |||
---|---|---|---|---|
EC50 or IC50 Values | nH | EC50 or IC50 Values | nH | |
Epibatidine (EC50) | 36.8 (25.4–53.4) nM | 0.9 | 34.7 (21.4–56.2) nM | 1.1 |
d-tubocurarine (IC50) | 5.5 (3.4–9.0) μM | −1.0 | 7.6 (5.6–10.5) μM | −0.8 |
Mecamylamine (IC50) | 0.2 (0.1–0.3) μM | −1.4 | 0.2 (0.1–0.4) μM | −1.1 |
KAB-18 (IC50) | 10.0 (5.5–18.0) μM | −1.2 | 110 (80.4–150) μMa | −0.6 |
KAB-24 (IC50) | 5.9 (3.8–9.2) μM | −1.1 | 9.7 (5.4–17.5) μM | −1.2 |
nH, Hill coefficient.
↵a Significant difference, P < 0.0001.