TABLE 3
Region 2 SAR studies
 | R | Hα4β2 nAChRs | Hα3β4 nAChRs | ||
|---|---|---|---|---|---|
| IC50 Value (μM)a | nH | IC50 Value (μM)a | nH | ||
| KAB-18 |  | 13.5 (9.7–18.5) | −0.7 | NA | |
| DDR-1 |  | 25.5 (17.2–37.7) | −1.1 | 13.2 (6.4–27.3) | −0.6 |
| DDR-2 |  | 10.6 (3.5–32.1) | −0.7 | 19.5 (6.7–56.9) | −0.6 |
| KAB-21 |  | 6.3 (1.9–20.9) | −0.9 | 18.5 (7.3–46.2) | −0.7 |
| DDR-19 |  | 2.8 (1.3–6.1) | −0.9 | 4.3 (1.6–11.4) | −0.9 |
| KAB-24 |  | 8.0 (4.2–15.3) | −1.2 | 5.5 (1.7–17.4) | −0.9 |
| KAB-22 |  | 9.4 (5.5–16.1) | −1.3 | 23.1 (11.1–48.2) | −1.2 |
| KAB-23 |  | 7.9 (4.9–12.7) | −0.7 | 12.1 (8.1–17.9) | −0.9 |
| KAB-19 |  | 5.5 (2.0–15.2) | −1.1 | 4.3 (1.0–17.7) | −0.9 |
| KAB-20 |  | 6.0 (4.4–8.2) | −1.5 | 5.9 (4.1–8.4) | −0.8 |
| KAB-30 |  | 4.9 (2.5–9.5) | −1.5 | 5.0 (3.0–8.3) | −1.3 |
| IB-2 |  | 10.5 (7.4–14.8) | −0.8 | 10.9 (5.1–23.3) | −0.9 |
nH, Hill coefficient; NA, no activity at concentrations up to 100 μM.
↵a Values represent geometric means (confidence limits), n = 4–8.