TABLE 3

Echocardiographic parameters for the effects of RGZ in HF and ZDF rats

RGZ3 and RGZ45 represent treatment of RGZ for 4 wk at 3 and 45 mg/kg p.o., respectively.

Parameter	Lewis Rats-Sham		Lewis-HF			ZDF Rats
Parameter	Vehicle	RGZ45	Vehicle	RGZ3	RGZ45	Vehicle	RGZ45
Ejection fraction (%)
Before dosing	80 ± 3	74 ± 3	37 ± 1	35 ± 1	36 ± 1	76 ± 2	73 ± 3
After dosing	79 ± 4	75 ± 3	31 ± 5	27 ± 3	34 ± 2	74 ± 1	81 ± 2^*
Fraction shortening (%)
Before dosing	50 ± 3	45 ± 3	19 ± 1	18 ± 1	18 ± 1	47 ± 2	44 ± 3
After dosing	50 ± 4	46 ± 3	16 ± 2	14 ± 2	18 ± 1	45 ± 2	52 ± 2
LVIDs (mm)
Before dosing	4.1 ± 0.3	4.6 ± 0.2	8.0 ± 0.4	8.8 ± 0.1	8.1 ± 0.2	4.4 ± 0.2	5.3 ± 0.6
After dosing	4.0 ± 0.5	4.8 ± 0.3	9.2 ± 0.6	9.3 ± 0.2	9.1 ± 0.3	4.7 ± 0.3	3.9 ± 0.2^*
LVIDd (mm)
Before dosing	8.1 ± 0.1	8.2 ± 0.1	9.9 ± 0.5	10.8 ± 0.1	9.9 ± 0.2	8.5 ± 0.2	8.0 ± 0.6
After dosing	7.9 ± 0.4	8.9 ± 0.2^*	11.0 ± 0.5	10.7 ± 0.3	11.0 ± 0.3	8.6 ± 0.4	7.9 ± 0.3
LVVs (μl)
Before dosing	74 ± 11	97 ± 11	360 ± 39	430 ± 5	353 ± 20	92 ± 9	108 ± 13
After dosing	78 ± 24	110 ± 15	490 ± 66	477 ± 21	464 ± 36	108 ± 14	64 ± 8^*
LVVd (μl)
Before dosing	359 ± 10	368 ± 14	566 ± 59	660 ± 15	551 ± 27	384 ± 18	399 ± 15
After dosing	335 ± 35	433 ± 20^*	699 ± 66	658 ± 35	704 ± 46	412 ± 35	336 ± 26
Stroke volume (μl)
Before dosing	285 ± 8	271 ± 13	206 ± 21	231 ± 13	198 ± 8	292 ± 14	291 ± 18
After dosing	257 ± 12	322 ± 10^**	210 ± 34	182 ± 28	240 ± 17	304 ± 28	272 ± 22
Cardiac output (ml/min)
Before dosing	109 ± 4	102 ± 9	80 ± 10	89 ± 6	75 ± 4	84 ± 4	83 ± 6
After dosing	96 ± 4	120 ± 5^**	78 ± 12	65 ± 11	79 ± 6	79 ± 7	74 ± 6