Parameter | Lewis Rats-Sham | Lewis-HF | ZDF Rats | ||||
---|---|---|---|---|---|---|---|
Vehicle | RGZ45 | Vehicle | RGZ3 | RGZ45 | Vehicle | RGZ45 | |
Body wt (g) | |||||||
Before dosing | 400 ± 7 | 401 ± 4 | 391 ± 6 | 412 ± 5 | 399 ± 9 | 359 ± 11 | 366 ± 6 |
After dosing | 420 ± 7 | 448 ± 5** | 421 ± 4 | 447 ± 6 | 447 ± 11 | 374 ± 15 | 450 ± 13** |
Heart wt (mg) | |||||||
Terminal | 986 ± 19 | 1107 ± 11 | 1070 ± 31 | 1154 ± 40 | 1171 ± 17 | 1021 ± 16 | 1152 ± 31** |
Heart/body wt (mg/g) | |||||||
Terminal | 2.3 ± 0.1 | 2.5 ± 0.1* | 2.5 ± 0.1 | 2.6 ± 0.1 | 2.6 ± 0.1 | 2.7 ± 0.1 | 2.6 ± 0.1 |
Lung wt (g) | |||||||
Terminal | 1169 ± 20 | 1205 ± 34 | 1911 ± 393 | 2211 ± 434 | 1621 ± 287 | 1147 ± 24 | 1167 ± 39 |
Lung/body wt (mg/g) | |||||||
Terminal | 2.8 ± 0.1 | 2.7 ± 0.1 | 4.6 ± 0.9 | 4.9 ± 1.0 | 3.7 ± 0.7 | 3.1 ± 0.1 | 2.6 ± 0.1 |
HR (beats/min) | |||||||
Before dosing | 393 ± 21 | 372 ± 18 | 383 ± 22 | 386 ± 10 | 379 ± 6 | 286 ± 6 | 283 ± 6 |
After dosing | 379 ± 20 | 367 ± 11 | 374 ± 8 | 351 ± 13 | 330 ± 12 | 260 ± 8 | 273 ± 3 |
BP (mm Hg) | |||||||
Terminal | 121 ± 4 | 125 ± 4 | 88 ± 4 | N.A. | 94 ± 6 | 113 ± 3 | 107 ± 3** |