Cardiac function and inflammation | | | |
BNP | B-type natriuretic peptide | Biomarker of HF | |
ANP | Atrial natriuretic peptide | Facilitate cardiac function | |
ACE | Angiotensin-converting enzyme | Involved in HF | |
Slc2a4 | Glucose transporter-4 | Glucose metabolism marker | |
TNF-α | Tumor necrosis factor-α | HF and inflammation marker | |
IL-6 | Interleukin-6 | HF and inflammation marker | |
IL-21 | Interleukin-21 | Inflammation | |
IL-22 | Interleukin-22 | Inflammation | |
Renal function and fluid retention | | | |
ENaCα | Epithelial Na+ channel | PPAR-γ-negative in kidney | Guan et al. (2005) |
ENaCβ | Epithelial Na+ channel | PPAR-γ-negative in kidney | Guan et al. (2005) |
ENaCγ | Epithelial Na+ channel | PPAR-γ-regulated in kidney | Guan et al. (2005) |
Slc9a3 | Na+-H+ exchanger, NHE3-gene Slc9a3 | Major apical sodium transporters in the kidney | Brooks et al. (2001) |
Npt2 | Na+-phosphate cotransporter, NaPi type II-gene Npt2 | Major functional transporters associated with renal Pi reabsorption | Zhao and Tenenhouse (2000) |
Slc12a1 | NKCC2, bumetanide-sensitive sodium-[potassium]-chloride cotransporter | Kidney Na+ transporter | Adrogue et al. (2007) |
Slc12a3 | Na+Cl− cotransporter, NCC-gene Slc12a3 | Na+ transporter | Adrogue et al. (2007) |
SGK1 | Serum and glucocorticoid-regulated kinase 1 | TZD activated | Hong et al. (2003) |
Ren1 | Renin 1 | PPAR-γ-regulated and a role in cardiac/renal function | Todorov et al. (2007) |
ROMK | Renal outer medullary potassium channel | Regulation of Na+ reabsorption | Lu et al. (2002) |
ATP1B1 | Sodium pump isoform β1 | Na+/K+ pump | McDonough et al. (1995) |
PPAR-γ | PPAR-γ | Autoregulated fluid retention and edema | Guan et al. (2005) |
Housekeeping gene | | | |
18S | 18S ribosomal RNA | Endogenous control | |
GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | Endogenous control | |
Ppla | Peptidylprolyl isomerase A (cyclophilin A) | Endogenous control | |
Hprt | Hypoxanthine guanine phosphoribosyl transferase | Endogenous control | |