Parameters | Cephalexin | Cefazolin | ||
---|---|---|---|---|
+/+ | −/− | +/+ | −/− | |
AUC0–60(μg·min/ml) | 351 ± 74 | 429 ± 97 | 653 ± 155 | 566 ± 85 |
AUC∞(μg·min/ml) | 414 ± 106 | 621 ± 160* | 734 ± 201 | 761 ± 171 |
CLtot(ml/min/kg) | 12.8 ± 3.1 | 8.7 ± 2.9* | 7.3 ± 2.1 | 6.8 ± 1.3 |
CLren(ml/min/kg) | 11.0 ± 3.0 | 6.5 ± 2.8* | 6.0 ± 1.9 | 6.5 ± 0.8 |
CLnr (ml/min/kg) | 1.8 ± 1.9 | 2.1 ± 1.0 | 1.3 ± 1.2 | 0.3 ± 0.6 |
Kp,kidney | 3.1 ± 0.5 | 13.8 ± 4.0*** | 1.8 ± 1.0 | 1.6 ± 0.2 |
Kp,liver | 1.5 ± 0.2 | 1.7 ± 0.8 | 1.1 ± 0.4 | 1.2 ± 0.5 |
Q (ml/min/kg) | 28.0 ± 11.3 | 21.6 ± 3.2 | 19.3 ± 8.6 | 14.9 ± 5.3 |
V1 (ml/kg) | 183 ± 15 | 144 ± 23** | 110 ± 21 | 125 ± 9 |
Vdss (ml/kg) | 426 ± 68 | 367 ± 45 | 209 ± 36 | 218 ± 39 |
Ccr (ml/min/kg) | 5.8 ± 1.5 | 5.3 ± 2.7 | 4.6 ± 2.0 | 5.2 ± 2.2 |
AUC0–60, AUC until 60 min; AUC∞, AUC from time 0 to infinity; CLtot, total body clearance; CLren, renal clearance; CLnr, nonrenal clearance; Kp,kidney, kidney-to-plasma concentration ratio; Kp,liver, liver-to-plasma concentration ratio; Q, intercompartmental clearance; V1, central volume of distribution; Vdss, volume of distribution at steady state.
↵* P < 0.05;
↵** P < 0.01;
↵*** P < 0.001 significantly different from Mate1(+/+) mice.