MAP and HR of different groups of rats before and after treatment with orexin receptor antagonists
The MAP and HR of each treatment group are expressed as the mean ± S.E.M.
| Treatment | No of Animals | MAP | HR | ||
|---|---|---|---|---|---|
| Before | 30 min After | Before | 30 min After | ||
| mm Hg | bpm | ||||
| TCS OX2 29 | |||||
| 0 nmol | 5 | 82 ± 8 | 81 ± 9 | 335 ± 21 | 335 ± 23 |
| 3 nmol | 5 | 88 ± 5 | 93 ± 5 | 378 ± 24 | 388 ± 22 |
| 10 nmol | 5 | 85 ± 4 | 87 ± 4 | 309 ± 23 | 322 ± 23 |
| SB-334867 | |||||
| 0 nmol | 5 | 78 ± 4 | 80 ± 2 | 294 ± 21 | 304 ± 15 |
| 3 nmol | 4 | 80 ± 1 | 81 ± 5 | 295 ± 18 | 309 ± 15 |
| 10 nmol | 6 | 81 ± 7 | 80 ± 8 | 330 ± 21 | 351 ± 22 |