Effects of E3710 and esomeprazole on 24-h intragastric pH in gastric fistula dogs in a crossover study
After 40 min of intravenous histamine infusion, 0.5% MC, E3710 at 0.4 mg/kg, or esomeprazole at 1.6 mg/kg was administered intraduodenally, and the measurement of intragastric pH was commenced at approximately 10:00 AM. Intragastric pH was measured for 24 h under free moving and free access to drinking water. The total food allowance per day was divided into two equal portions, which were separately offered to each dog at approximately 1:00 PM and 6:00 PM. Data are expressed as the mean ± S.E.M. (n = 6; 6 × 3 crossover study).
| Treatment | Mean pH/24 h | %Time with pH ≥4/24 h |
|---|---|---|
| 0.5% MC | 3.3 ± 0.2 | 20 ± 5 |
| E3710 (0.4 mg/kg) | 5.3 ± 0.3** | 82 ± 5**,# |
| Esomeprazole (1.6 mg/kg) | 4.6 ± 0.3* | 61 ± 7** |