TABLE 4

Effects of E3710 and esomeprazole on 24-h intragastric pH in gastric fistula dogs

After 40 min of intravenous histamine infusion at approximately 10:00 AM, 0.5% MC, E3710, or esomeprazole was administered intraduodenally, and the measurement of intragastric pH was commenced. Intragastric pH was measured for 24 h under free moving and free access to drinking water. The total food allowance per day was divided into two equal portions, which were separately offered to each dog at approximately 1:00 PM and 6:00 PM. Data are expressed as the mean ± S.E.M.

Treatment	n	Mean pH/24 h	%Time with pH ≥4/24 h
0.5% MC	27	3.2 ± 0.1	17 ± 3
E3710
0.2 mg/kg	4	3.7 ± 0.2	40 ± 6^*
0.4 mg/kg	8	5.1 ± 0.1^**	79 ± 3^**
0.8 mg/kg	5	5.5 ± 0.1^**	88 ± 2^**
Esomeprazole
0.8 mg/kg	4	4.0 ± 0.2^*	55 ± 3^**
1.6 mg/kg	8	4.3 ± 0.1^**	59 ± 4^**

↵* p < 0.01 vs. the 0.5% MC (Dunnett's multiple range test).
↵** p < 0.001.