TABLE 1

List of the dosages used in the surgical protocol

Molecular weight: monomer = 2311.49; dimer = 4621.0.

GroupDrugBolusInfusion
μmol/kg (mg/kg)μmol/kg/h (mg/kg/h)
M-1Monomer0.21 (0.5)0.54 (1.25)
M-1/10Monomer0.021 (0.05)0.054 (0.125)
M-2*Monomer0.43 (1.0)3.1 (2.5)
M-4Monomer0.86 (2.0)6.2 (5.0)
DDimer0.11 (0.5)0.27 (1.25)
DDDimer0.21 (1.0)0.54 (2.5)
  • * M-2 is not presented in the method of the present study (M-2 is part of an already published group) (Osipov et al., 2009b).