TABLE 1

Antiproliferative effects of RB24, RB10, gefitinib, and TEM in ErbB-negative cell line MDA-MB-435 and the ErbB-expressing cell lines MDA-MB-468 and MDA-MB-453

For MDA-MB-435, MDA-MB-468, and MDA-MB-453, values are means of IC50 values and S.E.M.s from three experiments.

CompoundMDA-MB-435MDA-MB-468Fold SelectivityMDA-MB-453Fold Selectivity
μMμM
RB247 ± 2.42.5 ± 0.22.81.3 ± 0.55.4
RB1041 ± 2.122.2 ± 1.61.818.3 ± 1.12.2
TEM18 ± 1.3>100>100
Gefitinib48 ± 1.918.4 ± 1.82.6N.D.

  • N.D., not determined.