PK/PD model estimated parameters for IFN-β and IP-10 mRNA
| Parameter (Units) | Definition | Estimate | %S.E.M. |
|---|---|---|---|
| Pharmacokinetic model parameter (rapid binding TMDD model) | |||
| kel (h−1) | First-order elimination rate constant | 29.5 | 24.2 |
| kpt (h−1) | First-order distribution rate constant from plasma to peripheral sites | 40.5 | 32.5 |
| ktp (h−1) | First-order distribution rate constant from peripheral sites to plasma | 1.36 | 19.7 |
| Vc (ml/kg) | Volume of the central plasma compartment | 46.5 | 14.8 |
| KD_WT (nmol/l) | Equilibrium dissociation constant in WT mice | 0.0950 | 39.4 |
| KD_KO (nmol/l) | Equilibrium dissociation constant in KO mice | 4.20 | 47.4 |
| Rtot,0 (nmol/l) | Total initial IFNAR receptor concentration | 29.9 | —a |
| kint (h−1) | First-order rate constant for internalization of IFNAR/IFN-β complex | 3.39 | 11.9 |
| Pharmacodynamic model parameter | |||
| kout (h−1) | First-order rate constant of IP-10 mRNA loss | 0.202 | 14.7 |
| Smax | Maximal stimulation capacity constant | 115 | 19.9 |
| S50 | Effective signal producing 50% of Smax | 0.183 | 37.5 |
| τ (h) | Mean signal transit time | 0.317 | 45.4 |
| γ (units) | Hill coefficient | 5 | —a |
↵a —, fixed value.