Noncompartmental parameter estimates for muIFN-β mean concentration-time profiles in mice
| Animal Strain (Dose) | λz | Cmaxa | AUC0-∞ | Vss |
|---|---|---|---|---|
| h−1 | IU/ml | h · IU/ml | ml/kg | |
| WT (0.5 MIU/kg) | 1.29 | 13.5 | 9.51 | 25,399 |
| KO (0.5 MIU/kg) | 0.930 | 135 | 134 | 3379 |
| WT (1 MIU/kg) | 0.317 | 107 | 142 | 10,036 |
| KO (1 MIU/kg) | 0.796 | 269 | 270 | 3154 |
↵a Maximal concentration for IFN-β.