TABLE 1

In vitro potency of PF-8380

AssayIC50
nM ± S.D.
Human enzyme FS-32.8 ± 0.16 (n = 4)
Human enzyme LPC1.7 ± 0.6 (n = 3)
Murine enzyme FS-31.16 ± 0.07 (n = 3)
Fetal fibroblast cell LPC1.15 ± 0.18 (n = 3)
Human whole blood101 ± 0.036 (n = 3)