IPA-identified proteins related to lipid metabolism in STZ-induced GDM
Control-standardized fold changes were generated for proteins linked to lipid metabolism. Differences of less than 10% were disregarded, and statistically significant deviations from control values were identified by using t tests. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Comparison values in the insulin-treated group were designated as no change (NC) when they were either not statistically different from those of controls or differed from controls by less than 10%.
| UniProt | Symbol | Entrez Gene Name | STZ | STZ + Insulin | ||
|---|---|---|---|---|---|---|
| Coverage | Fold Change | Coverage | Fold Change | |||
| % | % | |||||
| Q08201 | ABCB4 | ATP-binding cassette, subfamily B, member 4 (Mdr2) | 52.4 | 1.12** | — | — |
| P11497 | ACACA | Acetyl-CoA carboxylase α | 38.5 | −1.15*** | 33.8 | NC |
| P15650 | ACADL | Acyl-CoA dehydrogenase, long chain | 61.9 | 1.21*** | 37.9 | NC |
| P17764 | ACAT1 | Acetyl-CoA acetyltransferase 1 | 19.3 | −1.18** | — | — |
| P13601 | ALDH1A7 | Aldehyde dehydrogenase family 1, subfamily A7 | 45.1 | 1.18* | — | — |
| P04639 | APOA1 | Apolipoprotein A-I | 51 | 1.17* | 41.3 | NC |
| P10719 | ATP5B | ATP synthase, H+ transporting, mitochondria F1 complex, β polypeptide | 45.9 | −1.15* | 41.4 | NC |
| P21571 | ATP5J | ATP synthase, H+ transporting, mitochondria F0 complex, subunit F6 | 94.4 | −1.35* | 61.1 | NC |
| P01026 | C3 | Complement component 3 | 47.1 | −1.12* | 45.2 | NC |
| Q07969 | CD36 | CD36 molecule (thrombospondin receptor) | 41.1 | −1.25** | 31.8 | −1.19* |
| P20070 | CYB5R3 | Cytochrome B5 reductase 3 | 81.1 | −1.18* | 96 | NC |
| P08516 | CYP4A11 | Cytochrome P450, family 4, subfamily A, polypeptide 11 | 45.8 | 1.28* | — | — |
| P20817 | CYP4A14 | Cytochrome P450, family 4, subfamily A, polypeptide14 | 75.7 | 1.38* | 58.2 | NC |
| Q64654 | CYP51A1 | Cytochrome P450, family 51, subfamily A, polypeptide 1 | 65.2 | 1.2* | 52.7 | NC |
| P23965 | DCI | Dodecenoyl-CoA delta isomerase | 52.6 | 1.34** | — | — |
| Q64591 | DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | 50.7 | 1.12* | 32.8 | NC |
| P12785 | FASN | Fatty acid synthase | 45.5 | −1.22*** | 45.7 | NC |
| Q02769 | FDFT1 | Farnesyl-diphosphate farnesyltransferase 1 | 46.2 | 1.12** | 44.7 | NC |
| P05369 | FDPS | Farnesyl diphosphate synthase | 35.1 | −1.13* | 39.4 | NC |
| P43428 | G6PC | Glucose-6-phosphatase, catalytic subunit | 26.9 | 1.68* | 17.4 | NC |
| Q64232 | GPSN2 | Glycoprotein, synaptic 2 | 54.2 | −1.17** | 60.4 | NC |
| P06762 | HMOX1 | Heme oxygenase (decycling) 1 | 49.5 | −1.19* | — | — |
| P46720 | OATP1A1 | Solute carrier organic anion transporter family, member 1A1 | 27.2 | −1.14* | 28.4 | −1.17* |
| P02696 | RBP1 | Retinol binding protein 1, cellular | 29.6 | −1.16** | 48.1 | NC |
| Q8VHE9 | RETSAT | Retinol saturase (all-trans-retinol 12,14-reductase) | 69.3 | 1.29* | 66.3 | NC |
| P61589 | RHOA | Ras homolog gene family, member A | 39.9 | 1.13* | 43 | NC |
| P17475 | SERPINA1 | Serpin peptidase inhibitor, clade A, member 1 | 46.7 | 1.16* | 25.1 | NC |
| P97524 | SLC27A2 | Solute carrier family 27 (fatty acid transporter), member 2 | 70.3 | 1.21*** | 67.6 | NC |
| Q9ES38 | SLC27A5 | Solute carrier family 27 (fatty acid transporter), member 5 | 77.7 | 1.37** | 52.2 | NC |
| P24008 | SRD5A1 | Steroid-5-α-reductase, α polypeptide 1 | 35.5 | −1.23*** | 57.9 | NC |
| P61943 | ST3GAL6 | ST3 β-galactoside α-2,3-sialyltransferase 6 | 19.9 | −1.3* | — | — |
| Q64550 | UGT1A1 | UDP glucuronosyltransferase 1 family, polypeptide A1 | 63.2 | 1.3* | 57.2 | NC |