Table 1

Response parameters of multiple muscarinic agonists

Experiments were performed in quadruplicate, and maximal response is expressed as a percentage of [³H]AA release stimulated by 1 mM ACh. Data are the average of two or three experiments (mean ± S.E.M.).

	Log EC₅₀	E_max
		% max
CHO-M₁
Acetylcholine	−5.8 ± 0.04	100
Oxotremorine-M	−6.4 ± 0.03	113 ± 4.2
Oxotremorine	−6.9 ± 0.02	62 ± 1.2
Pilocarpine	−5.7 ± 0.0	52 ± 1.3
CHO-M₅
Acetylcholine	−7.6 ± 0.07	100
Oxotremorine-M	−7.6 ± 0.11	105 ± 4.2
Oxotremorine	−7.7 ± 0.15	72 ± 2.5
Pilocarpine	−6.1 ± 0.06	59 ± 1.2