EPS liability of lurasidone and other antipsychotics
ED50 values and 95% confidence limits in parentheses or MED values were obtained 1 h after drug administration.
| Drugs | Catalepsy Test in Rats | Paw Test in Rats | Catalepsy Test in Mice | Pole Test in Mice | ||||
|---|---|---|---|---|---|---|---|---|
| ED50 | Ratioa | MED | Ratioa | ED50 | Ratioa | MED | Ratioa | |
| mg/kg | mg/kg | mg/kg | mg/kg | |||||
| Lurasidone | >1000 | >430 | >1000 | >430 | >1000 | >240 | >1000 | >240 |
| Risperidone | 20 (9.3–43) | 11 | 30 | 17 | 0.85 (0.44–1.6) | 6.1 | 3 | 21 |
| Olanzapine | 28 (11–74) | 8.5 | 30 | 9.1 | >10 | >9.0 | 10 | 9.1 |
| Clozapine | >300 | >4.6 | 300 | 4.6 | >30 | >3.1 | >30 | >3.1 |
| Haloperidol | 12 (6.8–23) | 14 | 1 | 1.1 | 2.0 (1.1–3.5) | 4.5 | 1 | 2.3 |
↵a Ratio is calculated as the potency ratio of EPS measure to that of D2 antagonism (i.e., inhibition of MAP hyperactivity in rats and APO climbing behavior in mice).