Antipsychotic actions of lurasidone and other antipsychotics
ED50 values and 95% confidence limits in parentheses were obtained 1 h after drug administration.
| Drugs | ED50 (95% Confidence Limits) | |||||
|---|---|---|---|---|---|---|
| MAP-Induced Hyperactivity in Rats | APO-Induced Stereotyped Behavior in Rats | APO-Induced Climbing Behavior in Mice | Conditioned Avoidance Response in Rats | TRY-Induced Clonic Seizure in Rats | p-CAMP-Induced Hyperthermia in Rats | |
| mg/kg | ||||||
| Lurasidone | 2.3 (0.89–6.1) | 5.0 (3.6–6.9) | 4.1 (2.0–8.4) | 6.3 (3.4–12) | 5.6 (3.4–9.3) | 3.0 (1.5–5.8) |
| Risperidone | 1.8 (0.86–3.6) | 11 (6.2–18) | 0.14 (0.047–0.40) | 1.5 (0.89–2.4) | 0.16 (0.044–0.62) | 0.098 (0.039–0.25) |
| Olanzapine | 3.3 (1.5–7.3) | 5.1 (2.6–10) | 1.1 (0.35–3.2) | Not tested | 1.4 (0.59–3.3) | 0.62 (0.31–1.2) |
| Clozapine | 65 (29–140) | 290 (170–480) | 9.5 (3.8–24) | 38 (17–83) | 5.1 (2.6–10) | 5.0 (2.7–9.5) |
| Haloperidol | 0.88 (0.42–1.8) | 1.7 (1.2–2.5) | 0.44 (0.20–1.0) | 0.89 (0.48–1.7) | 14 (6.8–27) | >30 |