Parameter | Unit | [125I]EPO | [3H]HIRMAb-EPO |
---|---|---|---|
A1 | %ID/ml | 0.400 ± 0.002 | 0.251 ± 0.021 |
A2 | %ID/ml | – | 0.174 ± 0.015 |
k1 | min−1 | 0.00083 ± 0.00010 | 0.110 ± 0.025 |
k2 | min−1 | – | 0.0049 ± 0.0010 |
Median residence time | min | 1208 ± 151 | 191 ± 37 |
Vc | ml/kg | 44 ± 1 | 42 ± 2 |
Vss | ml/kg | – | 91 ± 7 |
AUC at 120 min | %IDmin/ml | 46.0 ± 0.2 | 18.0 ± 0.4 |
AUCss | %IDmin/ml | 486 ± 59 | 37.5 ± 4.6 |
Clearance | ml/min/kg | 0.037 ± 0.004 | 0.44 ± 0.05 |