Pharmacokinetic parameters for orally administered BaP in BNF-pretreated mice
Data from Fig. 3B were analyzed for determination of pharmacokinetics parameters. Values represent means ± S.D. (n = 6).
| Strain | Tmax | Cmax | t1/2 | AUC0-6 h |
|---|---|---|---|---|
| h | ng/ml | h | ng · h/ml | |
| WT | 0.92 ± 0.20 | 30 ± 10 | 0.38 ± 0.04 | 54 ± 11 |
| IE-Cpr-null | 1.50 ± 0.55 | 129 ± 43** | 1.31 ± 0.77** | 380 ± 56** |
↵** P < 0.01, compared with WT mice (Student's t test).