Experimental design
Plasma samples were collected hourly for 12 h following administration of APAP (15 mg/kg) or placebo at 8:15 AM on day 6. Study periods described above were randomized for order and conducted at least 1 week apart.
| Study Period | Days 1–3, Outpatient Equilibration | Days 4–5, Inpatient ± SAA | Day 6, Inpatient ± APAP |
|---|---|---|---|
| 1 | 3 Days with 100% RDA for SAA | 2 Days in GCRC with 100% RDA for SAA | Two sequential doses of APAP |
| 2 | 3 Days with 100% RDA for SAA | 2 Days in GCRC with SAA-free diet | Two sequential doses of APAP |