Percentage increases in the levels of extracellular concentrations of DA in the NAcb shell at ED50 doses (from Table 1) and at doses that produce maximal MA-associated responding in subjects trained to discriminate 0.3 mg/kg MA (see Fig. 4)
| Avoidance/Escape | Food Presentation | |||
|---|---|---|---|---|
| ED50 | Maximum Effect | ED50 | Maximal Effect | |
| % basal DA (95% CI) | ||||
| MA | 174 (5–342) | 329 (191–468) | 153 (−19 to 326) | 195 (31–359) |
| COC | 134 (47–220) | 380 (320–441) | 166 (85–247) | 380 (320–441) |
| GBR 12909 | 255 (14–497) | 449 (240–659) | 239 (−12 to 490) | 449 (240–659) |