Intrinsic clearance values for 5 μM NGB 2904 and PG 01037 in human and male Sprague-Dawley rat pooled liver microsomes (0.8 mg/ml)
Intrinsic clearance is reported as microliters per minute per milligram of protein (n = 3/reaction).
| Microsomal Preparation | Intrinsic Clearance (5 μM) | |
|---|---|---|
| NGB 2904 | PG 01037 | |
| Pooled human liver microsomes | 29.95 ± 3.83 | 25.62 ± 1.52 |
| Pooled male rat liver microsomes | 55.85 ± 3.05a,b | 26.20 ± 5.67 |
↵a P < 0.05 based on Newman-Keuls test, intrinsic clearance of NGB 2904 in human liver microsomes compared with rat liver microsomes.
↵b P < 0.05 based on Newman-Keuls test, intrinsic clearance of NGB 2904 in rat liver microsomes compared with intrinsic clearance of PG 01037 in human and rat liver microsomes.