TABLE 4

Pharmacokinetic parameters of MK2 inhibitors in Sprague-Dawley Rats

ClpaVdsst1/2CmaxbTmaxAUC0-∞bF
L/h/kgL/kghμMhμM×h%
PF-36440220.621.59.10.660.171.846
  • F, Absolute oral bioavailability.

  • a Parenteral administration, 1 mpk. n = 2

  • b Oral administration, 3 mpk. n = 3