TABLE 1

Dimebon plasma and brain concentrations (mean ± S.E.M.) after acute oral administration of cognition-enhancing doses used in the NOR task

Dose mg/kg	Plasma^{^a}	Brain^{^a}
	nM
0.05 mg/kg	0.15 ± 0.50	14.0 ± 94.1
0.5 mg/kg	1.0 ± 0.25	14.0 ± 5.1
5.0 mg/kg	13.9 ± 4.30	172 ± 94.1

↵a Samples taken approximately 50 min after oral dosing; n = 4/dose group.