Clobenpropit | Iodophenpropit | Capsazepine | |||||||
---|---|---|---|---|---|---|---|---|---|
IC50 | nH | n | IC50 | nH | n | IC50 | nH | n | |
μM | μM | μM | |||||||
Receptor | |||||||||
NR1/NR2A | 14 ± 2 | 1.3 | 10 | 1.3 ± 0.2 | 1.0 | 13 | 66 ± 9 | 1.1 | 7 |
NR1/NR2B | 1.0 ± 0.1 | 0.9 | 23 | 1.4 ± 0.2 | 0.9 | 15 | 8.1 ± 1.2 | 1.0 | 12 |
NR1/NR2C | 7.3 ± 0.3 | 1.1 | 8 | 9.7 ± 1.7 | 1.0 | 5 | 44 ± 5 | 1.1 | 8 |
NR1/NR2D | 11 ± 1 | 1.2 | 8 | 14 ± 1 | 1.2 | 7 | 42 ± 3 | 1.1 | 7 |
GluR1 | >100 | 4 | >100 | 4 | >100 | 4 | |||
GluR6 | 103 ± 1 | 0.7 | 12 | 53 ± 1 | 0.7 | 12 | N.E. | 4 | |
Mutant | |||||||||
NR1/NR2B-ΔATD | 7.4 ± 1.5 | 0.8 | 13 | 3.5 ± 1.1 | 0.6 | 7 | 74 ± 13 | 0.7 | 7 |
NR1(N616R)/NR2B | 4.8 ± 0.6 | 0.7 | 6 | N.D. | N.D. | ||||
NR1(N616R)/NR2B-ΔATD | 107 ± 29 | 0.5 | 6 | N.D. | N.D. |
N.D., not determined; N.E., no significant effect at 100 μM.