Receptor | Peak Current | Net Charge | Ratio |
---|---|---|---|
μM | |||
Activation: EC50 values for ACh (Fig. 10) | |||
α4(2)β2(3) (HS) | 1.5 ± 0.3 | 22 ± 9 | 14.6 |
α4(3)β2(2) (LS) | 155 ± 23 | 261 ± 28 | 1.68 |
α4β2α5 | 1.5 ± 0.4 | 20.5 ± 3.5 | 13.3 |
Antagonism of human α4β2 nAChR subtypes by decamethonium: IC50 values (Fig. 12) | |||
α4(2)β2(3) (HS) | 56 ± 3 | 60 ± 8 | 1.07 |
α4(3)β2(2) (LS) | 23 ± 1.5 | 33 ± 3 | 1.4 |
α4β2α5 | 43 ± 1.3 | 53 ± 3.5 | 1.23 |
Antagonism of human α4β2 nAChR subtypes by hexamethonium: IC50 values (Fig. 12) | |||
α4(2)β2(3) (HS) | 178 ± 25 | 23 ± 3 | 0.13 |
α4(3)β2(2) (LS) | 11.9 ± 1.3 | 1.9 ± 0.2 | 0.16 |
α4β2α5 | 23.5 ± 2.3 | 15.6 ± 0.8 | 0.66 |