TABLE 3
Selectivity of mecamylamine and DHβE for the inhibition of α3β4 and α4β2 receptors
IC
50
values
Mecamylamine
DHβE
μ
M
α4β2 Peak
21 ± 4
0.38 ± 0.04
α4β2 Charge
2.3 ± 0.3
0.09 ± 0.02
α3β4 Peak
0.33 ± 0.02
25 ± 1
α3β4 Charge
0.10 ± 0.01
25 ± 2