Genes altered by GLP-2/IgG2a treatment
| Location | Gene | Peak Fold Increase in Response to Surgical Manipulation | Peak Postoperative Time Point | Effect of GLP-2/IgG2a, P < 0.05 |
|---|---|---|---|---|
| h | ||||
| Muscularis Externa | ||||
| EGR-1 | 328 ± 41 | 1 | ↓ | |
| IL-6 | 187 ± 19 | 3 | ↓ | |
| IL-1β | 551 ± 95 | 6 | ↓ | |
| MCP-1 | 951 ± 102 | 6 | NC | |
| TNFα | 8.7 ± 0.2 | 3 | NC | |
| MIP-1α | 116 ± 10 | 0.5 | ↓ | |
| CSF-2 | 222 ± 22 | 6 | NC | |
| iNOS | 4.6 ± 1.4 | 3 | ↓ | |
| COX2 | 8.8 ± 0.9 | 0.5 | ↓ | |
| VIP | NC | NC | ||
| HO-1 | 40.8 ± 6.4 | 3 | ↑ | |
| CNR2 | 12.6 ± 1.3 | 6 | ↓ | |
| TLR3 | NC | NC | ||
| TLR4 | NC | NC | ||
| Mucosa | ||||
| EGR1 | 61.9 ± 8.9 | 1 | ↓ | |
| IL-6 | 289 ± 25 | 1 | ↓ | |
| IL-1β | 7.1 ± 0.8 | 1 | ↓ | |
| MCP1 | 28.0 ± 5.4 | 3 | NC | |
| TNFα | 2.5 ± 0.4 | 1 | NC | |
| MIP-1α | 7.7 ± 0.4 | 3 | ↓ | |
| CSF-2 | 63.7 ± 7.0 | 6 | NC | |
| iNOS | 2.7 ± 0.4 | 6 | ↓ | |
| COX2 | 4.8 ± 1.0 | 0.5 | ↓ | |
| VIP | NC | 0.5 | ↑ | |
| HO-1 | 21.1 ± 3.3 | 3 | NC | |
| Occludin | NC | 0.5 | ↑ | |
| Claudin 1 | 1.8 ± 0.2 | 6 | ↓ | |
| Claudin 3 | 1.5 ± 0.1 | 0.5 | ↓ | |
| TLR3 | NC | NC | ||
| TLR4 | NC | NC |
NC, No change in gene expression at any of the time points studied. ↑, Increased expression. ↓, Decreased expression.