Influence of dose, route, and pattern of exposure on DCE toxicokinetic parameter estimates
Rats were administered 10 or 30 mg/kg DCE as an oral bolus (p.o.) or over a 2-h period by constant gastric infusion (g.i.). Other groups of rats inhaled (inhal) 100 or 300 ppm DCE for 2 h. Serial arterial samples were taken for DCE analysis during and after exposures to characterize blood profiles. Values are means ± S.D. for groups of six rats.
| Dose | Cmax | Tmax | t1/2 | AUC02 | AUC0∞ | F |
|---|---|---|---|---|---|---|
| mg/l | min | μg · min/ml | % | |||
| 10 mg/kg p.o. | 2.2 ± 0.8a | 7 ± 5a | 47 ± 19a | 44 ± 15a | 51 ± 16a | 24.4 |
| 10 mg/kg g.i. | 0.2 ± 0.1b,A | 146 ± 34b,A | 78 ± 16a,A | 10 ± 3b,A | 33 ± 10a,A | 17.1 |
| 100 ppm inhal | 0.6 ± 0.1B | 55 ± 18B | 50 ± 24a,A | 62 ± 9B | 72 ± 10B | 39.4 |
| 30 mg/kg p.o. | 8.9 ± 4.1c | 5 ± 3a | 88 ± 29a | 222 ± 64c | 233 ± 8c | 46.5 |
| 30 mg/kg g.i. | 1.9 ± 0.7d,C | 128 ± 32b,C | 92 ± 38a,B | 89 ± 37d,C | 279 ± 107c,C | 40.1 |
| 300 ppm inhal | 2.8 ± 0.7D | 90 ± 35C | 50 ± 20a,B | 241 ± 57D | 279 ± 73c,C | 55.7 |
Values that are significantly different (p < 0.05) from one another are designated by different superscripts. Lowercase letters are used for comparison of p.o. and g.i. values, whereas uppercase letters are used for comparing g.i. and inhal data.