TABLE 1

Inhibition constant of PYR for the transport of [14C]TEA by HEK293 cells expressing organic cation transporters

Data shown in Figs. 1 and 7 were used to determine these parameters, which were calculated using nonlinear regression analysis as described under Materials and Methods. Each parameter represents the mean value ± S.E.

TransporterMouseHuman
MATE1145 ± 36 nM77 ± 13 nM
MATE2-K46 ± 6 nM
OCTN1>10 μMN.D.
OCTN2>30 μMN.D.
OCT13.6 ± 0.5 μM3.8 ± 0.3 μM
OCT26.0 ± 1.5 μM10 ± 1 μM
  • N.D., not determined.